A National Mission to Accelerate Science Through Artificial Intelligence (energy.gov)

The Department of Energy, with the White House OSTP and 17 National Labs, announced the "Genesis Mission": a national initiative to build an integrated scientific platform that links the nation’s top supercomputers, experimental facilities, AI systems, emerging quantum technologies, and secure multi-domain datasets. The goal is ambitious but concrete — double the productivity and impact of U.S. research within a decade by creating an “intelligent network” that can sense, simulate, and reason across scales, shortening discovery timelines from years to months and opening DOE resources to qualified researchers, universities, and industry partners. Technically, Genesis emphasizes real-time coupling of AI with high-performance computing, autonomous labs, digital twins, and ultrafast experiments to accelerate work from fusion and advanced nuclear designs to molecular dynamics, quantum algorithm discovery, materials science, and resilient grid planning. Key implications include generation of high-fidelity scientific datasets (not web-trained models), AI-guided design-and-test loops for reactors and materials, faster validation via autonomous instrumentation, and AI as a reasoning partner rather than mere automation. For the AI/ML community this means access to unique, curated training corpora and large-scale multimodal workflows that will push model capabilities in simulation, causal reasoning, and verification while directly impacting energy, national security, and foundational science.