Leap in DNA synthesis slashes time to build new genetic sequences (spectrum.ieee.org)

A groundbreaking method for DNA synthesis, named Sidewinder, was introduced at SynBioBeta 2026, significantly enhancing how scientists can construct novel genetic sequences. This innovative technique allows for the simultaneous assembly of multiple genetic sequences in a single test tube and boasts an impressive error rate of one incorrect junction per 10 million assembly events, far exceeding the precision of conventional methods. By utilizing affordable raw materials, Sidewinder addresses a critical bottleneck in genomics, enabling rapid and cost-effective testing of generative AI-produced DNA designs. Developed by a team led by Caltech's Kaihang Wang, Sidewinder utilizes molecular barcodes to ensure fragments of DNA assemble correctly, akin to page numbers in a manuscript. This advancement not only allows for high-throughput synthesis of lengthy sequences but also opens up vast applications in drug discovery, synthetic biology, and data storage. By reducing the assembly time from over a month to just a few days, Sidewinder promises to accelerate research in areas that rely heavily on AI-generated genetic data, positioning itself as a game-changer in the biotech industry. The team also plans to commercialize the technology through their new company, Genyro, aiming to make it accessible for academic and commercial use.